Adult Human Glioblastomas Harbor Radial Glia-like Cells

Adult Human Glioblastomas Harbor Radial Glia-like Cells

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Summary: Radial glia (RG) cells are the first neural stem cells to appear during embryonic development.Adult human glioblastomas harbor a subpopulation of sukrensi.com RG-like cells with typical RG morphology and markers.The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner.Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states.

Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor here progression.These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance.They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.: Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development.

They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.Keywords: radial glia, cancer stem cells, glioblastoma, inflammation, brain tumor, scRNASeq, tumor mitosis.